rotigotine HCl
(6S)-6-(propyl-(2-thiophen-2-ylethyl)amino)tetralin-1-ol hydrochloride
CAS: 125572-93-2
Molecular Formula: C19H26ClNOS
rotigotine HCl - Names and Identifiers
| Name | (6S)-6-(propyl-(2-thiophen-2-ylethyl)amino)tetralin-1-ol hydrochloride |
| Synonyms | (6S)- rotigotine HCl Rotigotine hydrochloride CEXBONHIOKGWNU-NUDVEOEASA-N [2H3]-RAC ROTIGOTINE HYDROCHLORIDE SALT 8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]aMino]- (6S)-6-(propyl-(2-thiophen-2-ylethyl)amino)tetralin-1-ol hydrochloride (S)-5,6,7,8-Tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-1-naphthalenol hydrochloride (6S)-5,6,7,8-Tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-1-naphthalenolhydrochloride (6S)-6-[propyl(2-thiophen-2-ylethyl)amino]-5,6,7,8-tetrahydronaphthalen-1-ol hydrochloride (S)-6-(propyl(2-(thiophen-2-yl)ethyl)amino)-5,6,7,8-tetrahydronaphthalen-1-ol hydrochloride |
| CAS | 125572-93-2 |
| EINECS | 603-080-0 |
| InChI | InChI=1/C19H25NOS.ClH/c1-2-11-20(12-10-17-6-4-13-22-17)16-8-9-18-15(14-16)5-3-7-19(18)21;/h3-7,13,16,21H,2,8-12,14H2,1H3;1H/t16-;/m0./s1 |
rotigotine HCl - Physico-chemical Properties
| Molecular Formula | C19H26ClNOS |
| Molar Mass | 351.93 |
| Density | 1.2g/cm3 at 20℃ |
| Melting Point | 114-117°C |
| Boling Point | 470.1°C at 760 mmHg |
| Flash Point | 238.1°C |
| Solubility | Acetone (Slightly, Heated, Sonicated), DMSO (Slightly), Methanol (Slightly) |
| Vapor Presure | 0-0Pa at 20-25℃ |
| Appearance | solid |
| Color | white to off-white |
| Storage Condition | room temp |
| In vitro study | Rotigotine (N-0923) has a 10-fold selectivity for D3 (pK i 9.2) receptors compared with D2, D4 and D5 (pK i 8.5-8.0) and a 100-fold selectivity compared with D1 receptors (pK i 7.2). In functional studies, Rotigotine (N-0923) behaves as full agonist at all dopamine receptors but notably the potency for stimulation of D1 receptors is similar to that for D2 and D3 receptors (pEC 50 respectively: 9.0, 9.4-8.6, 9.7). Rotigotine (N-0923) (10 µM) decreases the number of THir neurons by 40% in primary mesencephalic cell culture. Rotigotine (0.01 µM) slightly protects dopaminergic neurons against MPP + toxicity, significantly protects dopaminergic neurons against rotenone-induced cell death, and significantly inhibits ROS production by rotenone. |
| In vivo study | In primed rats, Rotigotine (N-0923) (0.035, 0.1 and 0.35 mg/kg) induces contralateral turning behavior in a dose dependent manner. In drug naive rats, the turning behavior induced by Rotigotine, either alone or in combination with SCH 39166, is reduced compared to primed rats. |
rotigotine HCl - Risk and Safety
| WGK Germany | 2 |
| HS Code | 2934990002 |
rotigotine HCl - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.841 ml | 14.207 ml | 28.414 ml |
| 5 mM | 0.568 ml | 2.841 ml | 5.683 ml |
| 10 mM | 0.284 ml | 1.421 ml | 2.841 ml |
| 5 mM | 0.057 ml | 0.284 ml | 0.568 ml |
Last Update：2024-01-02 23:10:35
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